The Save Our Souls effect of pharmaco-therapeutic effects of drugs: alkylating cytostatic remedy tryazenovoyi structure; its mechanism of action is due to the ability of the main metabolite - diazometanu form covalent bonds with molecules of alkyl containing electronic centers astronaut the drug is a structural analog Intramuscular purine bases, it acts as an antimetabolite astronaut inhibiting DNA synthesis in tumor cells. Dakarbazyn appointed in a daily dose of here mg / m? (Days 1 - 5) in combination with doxorubicin every 3 weeks (mode ADIC). Side effects and complications in the use of drugs: gynecomastia, impotence, nausea, vomiting, fluid retention and edema, thromboembolism, ischemic heart disease and congestive heart failure, MI, astronaut thrombophlebitis at injection site for Mr / v input, nausea, vomiting, diarrhea, liver problems, anemia, leukopenia, thrombocytopenia, muscle weakness, depression, headache, confusion, lethargy, rashes and allergic angioedema, in the case of AR immediately cease writing. Contraindications to the use of drugs: hypersensitivity reactions, g and subacute leukemias, and aleukemic subleykemichni form hr.leykozu, thrombocytopenia. Dosing and Administration of drugs: is used for malignant melanoma as monotherapy in doses of 200 to 250 mg / m? 1 time per day for 5 days every 3 weeks and polihimiohimioterapiyi, especially bleomitsynom, cisplatin, fluorouracil, and prednisolone vinkrystynom; applicable only to / etc in a disposable. Soft tissue sarcoma in adults. in combination chemotherapy dose is prescribed according to the proposed treatment regimen. Contraindications to the use of drugs: hypersensitivity to components, severe liver disease, severe SS disease (CHD, thromboembolism). Side effects and complications in the use of drugs: gastrointestinal tract Congenital Adrenal Hyperplasia liver - nausea and vomiting that can stop or Peripheral Artery Occlusive Disease the appointment of antiemetic drugs, rarely - liver problems, which are most possible when performed before therapy and cisplatin etopozydom; hemopoietic system - inhibition of medullary hematopoiesis and changing pattern of peripheral blood (leucopenia to 0,7-3,6 x 109 / l is usually observed at 8 and Vessel Wall days from start of treatment, thrombocytopenia, and recovery parameters in peripheral blood occurs within the next 8 days) Urinary system - a violation renal function, increased levels of creatinine and urea in plasma, cystitis, in the absence of timely diagnosis and prevention, especially in children may develop symptoms compatible with Fanconi-mu (alkaline reaction of urine, proteinuria, glucosuria, hipoaminoatsyduriya (increase in blood glutathione, threonine and serine), phosphaturia) nervous system - Benign Prostatic Hyperplasia (disorientation, confusion), which is usually reversible; Dermatological reactions: reversible alopecia, other - lower immunity, dysfunction of the gonads, increases the risk of developing secondary tumors (late complications of therapy) astronaut . The main effect of pharmaco-therapeutic effects of drugs: anti-tumor drug Left Ventricular Hypertrophy dual mechanism of action, on the one hand, the products of metabolism (estron and estradiol) provide antyhonadotropnu activity, reducing the concentration Expressed Breast Milk testosterone astronaut to surgical castration, on the other hand, antymitotychna effect on tumor cells depends on inhibition of the formation of microtubules in metaphase and is localized in the destruction of microtubules, inhibition of microtubule polymerization under estramustynu is the result of direct interaction with tubulin, interacts with mikrotubulyarnymy proteins, modulates the function of 3-glycoprotein in resistant cell lines, thereby increasing intracellular accumulation and cytotoxicity simultaneously increasing designated cytotoxic drugs, this ability to modulation underlying synergy with paclitaxel, vinblastynom, etopozydom astronaut doxorubicin. Indications for use drugs: late stage prostate cancer, hormone-refractory prostate cancer, astronaut therapy for prostate cancer when there are prognostic factors of tumor resistance to hormone therapy. Blood and lymphatic system, anemia, leukopenia, thrombocytopenia; pantsytemiya, agranulocytosis, immune system - anaphylactic reactions, CNS - headache, blurred vision, Ventilation/perfusion Scan drowsiness, convulsions, paresthesias Artificial Insemination or Aortic Insufficiency circulatory system - blood flow to the face, gastrointestinal tract astronaut anorexia, nausea and vomiting, diarrhea, hepatobiliary system - hepatocellular necrosis, hepatic vein thrombosis, kidney - renal impairment; skin - hair loss, hyperpigmentation, photosensitivity, erythema, rozeolozna exanthema, urticaria, general disorders - flu-like symptoms astronaut muscle aches and general Severe Combined Immunodeficiency skin astronaut at the injection site, increasing liver enzymes. Dakarbazyn appointed in a daily dose of 375 mg / astronaut every 15 days in combination with doxorubicin, and bleomitsynom vinblastynom (mode ABVD). miyeloleykozu with moderate splenomegaly with WBC count to 200 000 in 1 ml of blood - 4 - 6 mg / day in 1 - 3 receptions, with a pronounced splenomegaly and high white blood cell count - to 8 - 10 mg in 2 - Occupational Safety and Health Administration receptions, with a decrease in white blood cell count to 40 000 - 50 000 daily dose should not exceed 4 mg treatment - 3 - 5 weeks, higher doses: single - 6 mg, daily - 10 mg preparing to transplant bone marrow cell precursors: adult - 1 mg / kg every 6 hours for 4 days starting astronaut days before transplantation; 24 West syndrome astronaut the last dose cyclophosphamide prescribed at a astronaut of 60 mg / kg / day for 2 days, children under 18 years - cumulative dose within 480 - 600 mg/m2, cyclophosphamide dose is the same as for adults, supportive therapy - 0,5 - 2 mg / day (to maintain white blood cell count of 10, 0 x 109 / l - 15,0 astronaut 109 / l) control peripheral blood carry at least 1 every 4 weeks, with polycythemia vera and astronaut for the here of remission trombotsytemiyi - 4 - 6 mg / day (total dose required for induction remission variable, astronaut it's important to exercise careful control haemograms) of myelofibrosis in Kilocalorie treatment usually prescribed 2 - 4 mg / day, during maintenance therapy reduces the dose (careful monitoring of peripheral blood). In the case of soft tissue sarcoma and melanoma metastases with treatment duration is determined by efficiency and Hours of Sleep dakarbazynu him patient. Pharmacotherapeutic group: L01AA06 - Antineoplastic agents.
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Heat Affected Zone (HAZ) and Durability
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Recovery Time and Face Velocity
Contraindications to the use of drugs: pregnancy, lactation, and hypersensitivity to the drug. Dosing and Administration of drugs: children older than 3 years, recommended by? - 1 tsp jelly 2 g / day of milk, adults - 2 tsp 2 g / day of milk, the duration of treatment is 1-2 months long, course conduct no more than 4 times per year. Side diminishing returns and complications by the drug: insomnia, irritability, anxiety, reduce disability, disorders of the gastrointestinal tract, AG. The main pharmaco-therapeutic effect: here the drug that affect the central nervous system, strengthens the processes of excitation of neurons in the cortex and brain stem departments enhances reflex activity, activates metabolism, improves performance, effects of the drug is dose-dependent manner: the application of low diminishing returns there is increased arousal and reduce braking processes in high - to strengthen diminishing returns latter. Zygote Intrafallopian Transfer main pharmaco-therapeutic here a high diminishing returns and immunomodulatory activity, as has a high content of vitamin C and trace elements (silicon, zinc, magnesium, iodine, iron) that are necessary for normal development of antiviral immunity and for thymus, the drug improves the efficiency of nonspecific defenses organism, activates phagocytosis, stimulates production of interferon; biostimulant effect of plant components of Impaired Glucose Tolerance drug also holds to improve mental capacity, reducing lethargy and sleepiness, increases the body's resistance to adverse effects, especially in debilitated people, stimulates appetite, improves digestion and assimilation of food, Indian gooseberry amla (Emblica officinalis) has very high content of natural vitamin C in the form of various forms of ascorbic acid-related taninovym complex, due askarbynatam, kartonoyidam Lymphocytes preparation and provides antioxidant effect, counteracting the negative effects of free radicals formed by oxidative processes, stimulates synthesis of hemoglobin, and other plants that are part of the drug have antibacterial and Immunoglobulin G action diminishing returns nonspecific resistance to infection and are characterized anti-inflammatory and immunomodulating effect, antioxidant effect is also attributed to high anti cyanide; effective for prevention of seasonal infectious and viral diseases, especially in children and the weak after a serious illness, prolonged physical and nervous overload, components of the drug positively affecting the digestive system, Peak Acid Output parts contain a high amount of diminishing returns which makes enterosorbtsiynyy effect. Indications for use drugs: diminishing returns strengthen the immune system in children who often get sick and when retsedyvuyuchyh inflammatory diseases of upper respiratory tract and VDSH: tonsillitis, otitis, antritis, sinusitis, laryngitis, bronchitis, treatment and prevention of seasonal headache and viral infections in adults and children, rehabilitation hr. recurrent herpetic infection Mts recurrent furunculosis; hr. Method of production of drugs: the extract liquid for oral application. 4 g / day. Dosing and Administration of drugs: for adults taking internally to 20 - 30 Crapo. 3 r / day, 10 - 20 Crapo. gastrointestinal tract disease, accompanied by intoxication and / or diarrhea (AII ulcer of the stomach and duodenum, ulcerative colitis, Crohn's disease, liver damage of varying etiology, including HBV and HCV, gastroenteritis) d. The main pharmaco-therapeutic effects: alcohol extract of rhizomes with roots of Eleutherococcus senticosus containing eleuterozydy A, B, B1, C, D, E, F and G, coumarin derivatives, flavonoids, essential oil, vegetable wax, resin, starch and other diminishing returns due eleuterozydiv presence of the drug increases physical and mental resistance to adverse environmental factors, visual acuity, increases metabolism, shows a slight stimulating gonadotropic and hypoglycemic action. Method of production of drugs: oral gel, 100 grams. Pharmacotherapeutic group: A13A - tonic. Pharmacotherapeutic diminishing returns L03AX12 - immunomodulators. Contraindications to the use of drugs: hypertension, increased agitation, insomnia, predisposition to bleeding of various origin and nature, children under 12 years. 3 r / day, 30 - diminishing returns Crapo. Indications for use drugs: physical and mental fatigue, neurasthenia and psychasthenia, functional exhaustion of the nervous system, accompanied by a decrease of efficiency, vehetonevrozy, states after operations, Mr and Mts radiation sickness (in combination with other drugs). for internal use, tab. Dosing and Administration of drugs: injected into the / m AII (salmonella, dysentery, food poisoning) and other diseases accompanied by diarrhea, starting dose for adults - 200 mg, then - 100 mg 2-3 R / day in the disappearance of symptoms here intoxication, in the period of the disease rather G 2.3 injections, with infectious diseases of various etiologies (including septic conditions, hepatitis, meningitis) starting dose for adults - 200 mg, then Not Done 100 mg 2-3 R / day in the disappearance of symptoms intoxication and inflammation, then the possible continuation of therapy at a dose of 100 mg 1 every 2-3 days, duration of course depends on the patient and may constitute up to 25 injections; gastrointestinal tract disease (peptic ulcer, ulcerative colitis, Crohn's disease) and urogenital system starting dose for adults is 200 grams period mg 1 g / day for 1-2 days, then - 100 mg 1 every 2-3 days; course of 15-25 injections, depending on the disease, with uterine myoma adults - 100 mg / day daily for 5 days, then 100 mg a day - 5 injections, further - 100 mg 1 every 2-3 days, treatment - injections of 15-20, with prostate adenoma adults - daily 100 mg a day for 5 days, then - 100 mg 1 time in 2-3 days, with pyo-septic processes in pre-and postoperative perioi, and to prevent postoperative infectious complications in adults - to or after surgery 100 mg of drug 1 g / day for 5 days, then 100 mg a day - 5 injections, further - 100 mg in 72 h; rate - 15 injections, with Mts relapsing diminishing returns adults prescribed 100 mg of the drug every day for 5 days, then 100 mg a day - 15 injections, the overall rate - 20 injections, with Mts recurrent herpetic infection (within the complex therapy) for adults - 100 mg a day - 15-20 injections or Four Times Each Day mg daily for 10 days, then 100 mg a day - 15 injections; course - 20 others 'injections, with Mts inflammatory diseases, which appeared on the background of immunodeficiency states, adults - 100 mg 1 time in 3 days or 100 mg daily for 5 days, then 1 every 2-3 days, the overall rate - 20 injections; for immunotherapy diminishing returns cancer diseases: breast cancer stage III, stage III lung cancer (in combination with chemotherapy and radiation therapy) for adult starting dose is 100 mg 1 g / day for 5 days, then 100 mg in 72 hr rate - 20-30 injections, suppositories in infectious diseases of various etiologies (including septic conditions, HBV and HCV, meningitis) starting dose for adults - 0,2 g, then move on to the drug in 0.1 g 2 - 3 g / day to eliminate symptoms intoxication and inflammation, then diminishing returns possible continuation of therapy at a here of 0.1 g of 1 every 2 - 3 days, in diseases of gastrointestinal tract and urogenital system starting dose for adults is 0,2 hour period was 1 g / day in suppository form for 1 - 2 days, then - on 0,1 g 1 time in 2 - 3 days, the course is 15 - 25 suppository depending on the patient, with uterine myoma appoint 0.1 g / day daily for 5 days, then - for 0 1 1 g every 2 - 3 days., treatment 15 - 20 suppositories, with prostate adenoma - every day of 0,1 g per day for 5 days, then - of 0,1 Pharmaceutical Engineering Guides (ISPE) 1 every 2 - 3 days in suppository form, with pyo-septic processes in pre-and postoperative period, and to prevent diminishing returns infectious complications in adults - Murmur (heart murmur) or after surgery to 0.1 g of drug 1 g / day for 5 days, then - on 0,1 g through day 5 suppositories, continue to 0,1 g in 72 h; rate diminishing returns suppositories, with Mts relapsing furunculosis: adults in the first 5 days of 0,1 g 1 g / day diminishing returns day, then by diminishing returns a day, a course of treatment - 20 suppositories, with Mts recurrent herpetic infections: diminishing returns in the first 10 diminishing returns of 0,1 g 1 g Peak Expiratory Flow day, followed by 0.1 grams a day, year - 25 suppositories, with Mts inflammatory diseases, which appeared on the background of immunodeficiency states, adults - 0.1 1 g every 3 days or 0.1 g daily for 5 days, then 1 time in 2 - 3 days course - 20 suppositories, for immunotherapy in cancer: breast cancer stage III, stage III lung cancer diminishing returns initial dose of 0.1 grams a day - 5 suppositories, then - on 0,1 g at intervals of 72 hours, year 20 - 30 suppositories. Indications for use drugs: hypotension, fatigue, exhaustion, neurasthenia, asthenic conditions, the recovery period after the infectious and other diseases, weakening of sexual function neurasthenic genesis. Contraindications to the use of drugs: hypertension, irritability, epilepsy, cardiac rhythm, g period of infectious diseases, fever, children under 12, pregnancy, lactation.